| 摘要 |
Compounds of the formula <IMAGE> <IMAGE> WHEREIN R1 is hydrogen or methyl, M IS 0 OR AN INTEGER FROM 1 TO 8, INCLUSIVE, AND Ar is <IMAGE> (a) WHERE R is hydrogen or acyl, and R2 is hydrogen or -OR, as defined above, <IMAGE> (b) WHERE R has the meanings defined above, and R3 is hydroxy-lower alkyl, -NH-CO-R4, -NH-SO2-R5, -CH2-NH-CO-R4, -CH2-NH-SO2-R5 or -CH2-NH-CO-NH-R4, where R4 is hydrogen or lower alkyl, and R5 is lower alkyl or di-lower alkyl-amino, <IMAGE> (c) WHERE R6 is hydrogen, amino or hydroxyl, X is chlorine or bromine, and Y is hydrogen, chlorine or bromine OR <IMAGE> (d) WHERE R has the meanings defined above, and A is a saturated or unsaturated 5- to 6-membered ring, AND THEIR NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS BRONCHOSPASMOLYTICS, UTERINE SPASMOLYTICS, ANTIPRURITICS AND ANTIALLERGICS.
|
