发明名称 |
Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
摘要 |
This invention relates to novel X-ray contrast agents particularly for use in the cerebrospinal cavities, comprising non-ionic alkanols carrying at least one N-bonded secondary or tertiary amide group and having at least two hydroxyl groups and at least one iodine atom in the molecule. Particularly useful compounds include the N-hydroxyalkyl iodoalkane sulphonamides having at least two hydroxyl groups, tri- and tetra-iodobenzene carrying carbamoyl, acylamino and/or acylaminomethyl substituents and having at least two hydroxyl groups in the molecule and at least one N-hydroxyalkyl group. Particularly preferred compounds comprise 2,4,6-triiodobenzamides which may be 3- and/or 5-substituted with a variety of groups. The compounds all show markedly low toxicities and a number show very high levels of water solubility.
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申请公布号 |
US4021481(A) |
申请公布日期 |
1977.05.03 |
申请号 |
US19740528842 |
申请日期 |
1974.12.02 |
申请人 |
NYEGAARD & CO. A/S |
发明人 |
ALMEN, TORSTEN;HAAVALDSEN, JOHAN;NORDAL, VEGARD |
分类号 |
A61K49/04;(IPC1-7):C07C103/26;A61K29/02 |
主分类号 |
A61K49/04 |
代理机构 |
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地址 |
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