WERKWIJZE TER BEREIDING VAN EEN FARMACEUTISCH PREPARAAT EN WERKWIJZE TER BEREIDING VAN L-VAL10- -SOMATOSTATINE.

摘要

A tetradecapeptide of the formula is prepared by converting the two sulphydryl groups which are contained in the cysteinyl portions in an appropriate straight-chain tetradecapeptide into a disulphide bridge by oxidation. The straight-chain tetradecapeptide employed as the starting compound can be obtained from a corresponding tetradecapeptide containing protective groups by removing the protective groups with hydrogen fluoride. The novel tetradecapeptide and also its non-toxic, pharmaceutically acceptable acid addition salts inhibit the release of growth hormone and also the secretion of gastric acid.