发明名称 |
NEW ANTIBIOTIC ROSEORBICINS A AND B* AND THEIR PREPARATION |
摘要 |
NEW MATERIAL:Antibiotic roseorbicin A of formula I: red powder; melting point 143-147 deg.C; molecular weight 1043.2; and antibiotic roseorbicin B of formula II: red powder; melting point 122-124 deg.C; molecular weight 684.8. USE:Carcinostatics capable of inhibiting propagation and nucleic acid synthesis of mouse leukemia cell, having a strong antitumor actions on experimental tumors, with a slight toxicity. PROCESS:Strains of the genera Streptomyces and Actinomyces are cultured at 20- 32 deg.C for 2-6 days by the aerobic submerged culture, and the bacterium bodies and the filtrate are extracted with a neutral organic solvent. The extract is purified and separated by column chromatography to give roseorbicins A and B. The roseorbicin A is hydrolyzed with a dilute acid and converted into roseorbicin B. |
申请公布号 |
JPS5547699(A) |
申请公布日期 |
1980.04.04 |
申请号 |
JP19780120510 |
申请日期 |
1978.09.29 |
申请人 |
SANRAKU OCEAN CO |
发明人 |
OKI SHIYUNICHI;YOSHIMOTO AKIHIRO;INUI TAIJI;TAKEUCHI TOMIO;UMEZAWA HAMAO |
分类号 |
C12P19/56;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07H15/24;C07H15/252;C12R1/04;C12R1/465 |
主分类号 |
C12P19/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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