AZOLYL-1-METHANES AND THEIR SALTS PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

摘要

1469617 Azolyl-1-methanes; their preparations and pharmaceutical compositions BAYER AG 23 Oct 1975 [24 Dec 1974] 43594/75 Heading C2C The invention comprises compounds of general Formula (I) in which R1 represents a halogen atom or a halogenoalkyl, alkyl, alkoxy, benzyl, nitro or cyano group; R2 represents an alkyl or optionally substituted aryl group; X represents a direct bond, an oxygen or sulphur atom or a thionyl or sulphonyl group; Az represents an imidazolyl-(1), pyrazolyl-(1), 1,2,4-triazolyl-(1) or 1,2,4-triazolyl-(4) group and n represents 0 or an integer of from 1 to 4 the radicals R1 being identical or different when n is greater than 1 and salts of said compounds which may be prepared by reaction of a carbinol of formula (II) with a thionyl bis azole of Formula (III) or reacting a halogenomethane of Formula (IV) wherein Hal represents chlorine or bromine with a compound having one of the Formulae (V) to (VII) where M is silver on an alkali metal, and wherein the products thus obtained, if desired, are reacted to form salts. 1-Diphenyl-1-phenylcarbinol is prepared by reacting 4-phenylbenzophenone with sodium borohydride. Pharmaceutical compositions having antimycotic and antibacterial activity for oral, rectal or parenteral administration comprise at least one compound of Formula I in admixture with a solid or liquefied gaseous diluent or in admixture with a liquid diluent other than a solvent of molecular weight less than 200 except in the presence of a surface active agent.