| 摘要 |
<p>2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-¨AD2-(pyrido¨AD2,3-d¨BDpyrimidin-6-yl)alkyl¨BD-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8- tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-(4-¨AD2-(2-amino-4-hydroxy-5,6,7,8,-tetrahydropyrido¨AD2-3-d¨BDpyrimidin-6-yl)-ethyl¨BDbenzoyl)-L-glutamic acid.</p> |
