发明名称 |
Intermediates in the production of tricyclic benzodiazepines |
摘要 |
Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
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申请公布号 |
US4014916(A) |
申请公布日期 |
1977.03.29 |
申请号 |
US19760676091 |
申请日期 |
1976.04.12 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
DERIEG, MICHAEL EDWARD;EARLEY, JAMES VALENTINE;FRYER, RODNEY IAN;STERNBACH, LEO HENRYK |
分类号 |
C07D213/24;C07D243/16;(IPC1-7):C07C69/96 |
主分类号 |
C07D213/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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