| 摘要 |
1467383 Daunomycin analogues SOC FARMACEUTICI ITALIA SpA 22 May 1975 [12 June 1974] 26083/74 Heading C2C Novel daunomycin analogues of the general formula wherein (a) each R 1 is a hydrogen atom and each R is a hydrogen, chlorine or bromine atom or a methyl or methoxy group or (b) each R 1 is a chlorine or bromine atom or a methyl group and each R is a hydrogen atom, are prepared by condensing 2,3,6-trideoxy-3-trifluoroacetamido- 4 - O - trifluoroacetyl -α- L - lyxopyranosyl chloride with the appropriate anthracyclinone in an anhydrous solvent in the presence of mercuric oxide and/or bromide and a molecular sieve, treating the resulting N,O-protected daunomycin analogue with methanol to eliminate the O-trifluoroacetyl group on the sugar moiety and then treating the resulting N-protected derivative with an alkali. (Œ) 4-Demethoxy-daunomycinone is prepared by subjecting the corresponding 7-methyl ether to ether-cleavage. |
