| 摘要 |
<p>Novel cyclopentanoic acid derivatives of the formula <IMAGE> I wherein R is selected from the group consisting of <IMAGE> and -CH2OH, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and a non toxic, pharmaceutically acceptable cation and R1 is selected from the group consisting of hydrogen, 2-tetrahydropyranyl, branched or straight chain, saturated or unsaturated alkyl of 1 to 4 carbon atoms and <IMAGE> and R2 is selected from the group consisting of straight or branched chain alkyl of 1 to 12 carbon atoms and phenyl with the alkyl and phenyl being optionally substituted with -COOA wherein A is selected from the group consisting of hydrogen, alkali metal, ammonium ion, ion of an organic amine, alkyl and haloalkyl of 1 to 7 alkyl carbon atoms with the proviso that R1 is not hydrogen or 2-tetrahydropyranyl when R is a carboxylic group, and the OH and R groups on the ring and OR1 group on the chain may be in either of the two possible positions about the carbon atom to which they are attached having analgesic, anti-inflammatory and smooth muscle relaxant activity.</p> |
