HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR 3

摘要

Disclosed is a human VEGF3 polypeptide and DNA (RNA) encoding such VEGF3 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF3 coding sequence and alterations in the concentration of VEGF3 protein in a sample derived from a host are also disclosed.