| 摘要 |
PURPOSE:To produce L-homophenylalanine useful as a raw material for a precursor of ACE inhibitor, having high optical purity, efficiently and inexpensively by treating benzylpyruvic acid with a culture mixture or cells of bacterium having specific action. CONSTITUTION:Benzylpyruvic acid (substrate concentration: about 0.1-5%) is treated with a culture mixture of a bacterium such as Corynebacterium glutamicum ATCC 13032 belonging to at least one of Corynebacterium, Brevibacterium, Bacillus, Microbacterium, Citrobacter, Arthrobacter and Escherichia, capable of converting benzylpyruvic acid into L-homophenylalanine or cells or treated material thereof at 20-40 deg.C, preferably 25-35 deg.C at pH7.5-9.0 and L-homophenylalanine is isolated from the reaction solution and collected. |
