发明名称 |
TDP-43-BINDING POLYPEPTIDES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
摘要 |
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-.kappa.B in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease. |
申请公布号 |
CA2874083(A1) |
申请公布日期 |
2016.06.05 |
申请号 |
CA20142874083 |
申请日期 |
2014.12.05 |
申请人 |
UNIVERSITE LAVAL |
发明人 |
JULIEN, JEAN-PIERRE;GRAVEL, CLAUDE;POZZI, SILVIA |
分类号 |
C07K16/18;A61K39/395;A61P25/00;C07K16/46;C12N5/10;C12N15/13;C12N15/864 |
主分类号 |
C07K16/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|