PREPARATION OF CONTROLLED DRUG RELEASE AND METHOD OF ITS PREPARING, METHOD OF TREATMENT

摘要

FIELD: pharmacy. SUBSTANCE: invention relates to a new oral pharmaceutical preparation consisting of at least 50 individual particles, their size is from 0.2 to 3 mm. Each particle including a morphine salt-containing corn is covered by protective layer providing the controlled, preferably pH-independent morphine release. To obtain the new morphine preparation particles are subjected for covering process in fluidized layer using covering liquid as a solution, dispersion, suspension or emulsion. Preparation is used for anesthetization and relieve of severe chronic pains exhibiting sensitivity to opioids. Preparation is given once per a day that provides the significant decrease of morphine concentration fluctuation in blood plasma as compared with its the known preparations. EFFECT: improved quality and properties of the preparation. 15 cl, 1 dwg, 10 tbl, 3 ex