PROCESS FOR THE PREPARATION OF 1-SUBSTITUTED 2-METHYL-TETRA HYDROPYRIMIDINES

摘要

1464829 1 - Substituted - 2 - methyl - tetrahydropyrimidines BAYER AG 15 Aug 1975 [17 Aug 1974] 34076/75 Heading C2C A process for preparing a 1-substituted-2- methyl-tetrahydropyrimidine comprises reacting an N-substituted propylene diamine with an acetoacetic acid ester or amide at a temperature of from 0‹ to 80‹ C. and removing the water produced in the reaction at a temperature of from 0 to 80‹ C. The process is preferably carried out in the presence of an inert solvent. The water of reaction may be removed by distillation or by addition of an inert dehydrating agent.