4-Benzazonine derivatives and process for preparation thereof

摘要

Novel 4-Benzazonine derivatives and their salts, and processes for the preparation thereof are disclosed. These 4-benzazonine derivatives are represented by the following general formula: <IMAGE> wherein R stands for -H, -OH or a lower alkoxy group such as -OCH3, R1 designates -H or a lower alkyl group such as -CH3 and -CH2CH3, R2 indicates -H or a lower alkyl group such as -CH3, R3 stands for -H, a linear or branched, saturated or unsaturated alkyl group having 1 to 4 carbon atoms, a mono- or di-hydroxy lower alkyl group such as -CH2OH and <IMAGE> a saturated cyclic hydrocarbon group having 3 to 6 carbon atoms or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 8 carbon atoms, and R4 designates -H, -OH or = O. These compounds have medicinal effects, especially therapeutic activities on the central nervous system, such as analgesic, antitussive and sedative activities.