| 摘要 |
<p>Novel chromanol derivs. of formula (I) and their acid-addn. salts. (where n = 3 or 4; X is 1-4C alkylene; R is H or Me; R1 and R2 are H or 1-4C alkyl, or together form part of a 5- to 7-membered alicyclic ring and in partic. were R1 = R2 = Et, X = (CH2)3, R=H, and n=3, and its acid-adn. salts. are water-soluble ester forms of the antihypertensive chromanol derivs. (II) described in the Parent Patent; they can be administered by injection as well as orally. Cpds. (I) can be prepd. by acylating the corresp. chromanol of formula (II): with a reactive deriv. of an acid of formula R1R2N-X-COOH, pref. an acid-addn. salt of the corresp. acid halide or anhydride or of the free acid in the presence of a dehydrating agent, e.g. dicyclohexylcarbodiimide (DCCD).</p> |
