PREPARATION OF ALKYL ESTERS A-L-ASPARTYL-L-PHENYLALANINE

摘要

1464139 Alkylesters ofα-L-aspartyl-L-phenylalanine MONSANTO CO 4 Nov 1974 [5 Nov 1973] 47533/74 Heading C3H A process for the preparation of anα-L- aspartyl-L-phenylalanine C 1 to C 3 alkylester comprises esterifyingα-L-aspartyl-L-phenylalanine with a C 1 to C 3 alkanol in the presence of a solvent at a temperature of from -20‹ C. up to the boiling point of the reaction mass. Theα-L-aspartyl-L-phenylalanine can be prepared by reacting N-protected-L-aspartic anhydride with L-phenylalanine to form N-protected-α- L-aspartyl-L-phenylalanine and removing the protecting group from the N-protected-α-L- aspartyl-L-phenylalanine.