| 摘要 |
<p>1464300 Prostaglandins YAMANOUCHI PHARMACEUTICAL CO Ltd 24 Sept 1974 [25 Sept 1973 27 Sept 1973 15 April 1974] 41543/74 Heading C2C The invention comprises prostaglandins of the Formulµ I and II wherein A is C=O or C(H) ÀÀÀ OH; one of R 3 and R 4 is H and the other of them is C 1-4 alkyl; one of R 5 and R 6 is H and the other of them is hydroxy; and one of R 7 and R 8 is H and the other one of them is C 1-4 alkyl; one of R 1 and R 2 is H and the other of them is a protected hydroxy group; and R 9 is a protective group for a hydroxy group and their preparation. The compounds are prepared by reacting 4#-[3-(2- tetrahydropyranyloxy) - 4 - methyl - 1 - transoctenyl] - 5α- (2 - tetrahydropyranyloxy)- 3,3a#,4,5,6,6a# - hexahydro - 2H - cyclopenta- [b]furan - 2 - ol with (4 - carboxypentyl)triphenylphosphonium bromide or (4-carboxy-2- methylbutyl)triphenylphosphonium bromide, if desired, hydrolysing the resulting compounds, or oxidizing the products so obtained, and then hydrolysing the oxidation products. 4# - [3 - (2 - Tetrahydropyranlyoxy)- 4- methyl - 1 - trans - octenyl] - 5α- (2 - tetrahydropyranyloxy) - 3,3a#,4,5,6,6a# - hexahydro - 2H- cyclopenta[b]furan-2-ol is obtained by reducing the corresponding cyclopenta[b]p-uran-2-one. The compounds possess similar pharmacological properties to the corresponding naturally occurring prostaglandins.</p> |
