| 摘要 |
<p>1382958 Esters of biphenylalkanoic acids with azabicycloalkanols G D SEARLE & CO 19 July 1973 [21 July 1972] 34578/73 Heading C2C Novel compounds of Formula I wherein Alk represents an alkylene radical containing 2 to 7 carbon atoms and Az represents the residue of an azabicycloalkanol containing 7 or 8 carbon atoms and a nitrogen atom in the ring structure, the ring structure optionally containing a keto group next to the nitrogen atom with the proviso that the nitrogen atom is substituted when no keto group is present and optionally substituted when the keto group is present are prepared by reacting the biphenyl alkanoic acid or a derivative thereof with the alcohol A 2 OH to form the ester. Biphenyl alkanoic acid chlorides are prepared by action of SOCl 2 on the acid. Azabicycloalkanols are prepared by LiAlH 4 reduction of the 3-keto-azabicycloalkanol. 2 - Ethyl - hexohydroxy - 2 - aza - bicyclo - [2,2,2]- octan-3-one is prepared from 3-carbomethoxy-7- oxabicyclo-[4,1,0]-heptane and ethylamine. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having antiviral, antihypercholesterolemic and hypolipermic activity comprise an above novel compound and a carrier or diluent.</p> |
