摘要 |
<p>5-Substd.-3-methyl-2-benzoteran acetic acids of formula (I) and their salts are new: (R=2-6C alkyl, 1-6C alkoxy, 3-6C cycloalkyl, 3-6C cycloalkoxy, 3-4C alkenyl, 3-4C alkenoloxy, cyclohexenyl, R1-substd. phenyl, phenoxy, R1-substd. benzyl, CF3, F or Br. R1=H, 1-4C alkyl, CH3O or halo). They are prepd. e.g. by hydrolysis of corresp. 2-cyanomethyl cpds. Also new are pharmaceutical compsns. contg. (I) or the known cpds. having R=H, CH3 or Cl. A specifically claimed cpd. 5-methoxy-3-methyl-2-benzo b furylacetic acid, was prepd. in 56% yield from corresp. 2-cyanomethylbenzofuran by refluxing for 10 hr. with 10% aq. NaOH.</p> |