METHODS AND COMPOSITIONS FOR REDUCING THE TASTE OF PHARMACEUTICALLY ACTIVE AGENTS

摘要

The present invention provides methods and compositions for reducing the perception of poor-tasting pharmaceutically active agents in the oral cavity. The invention provides particles containing one or more pharmaceutically active agents, flavorants and cellulosic materials, as well as methods for making same and for incorporating same into pharmaceutical dosage forms. In certain embodiments, the particles have a diameter of up to about 1000 micrometers and include the pharmaceutically active agent, a flavorant, and at least one cellulosic material that is microcrystalline cellulose, microcrystalline cellulose coprocessed with a hydrocolloid, or any combination thereof, individually or in admixture with a hydrocolloid.