| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention reveals how to procure polypeptide forms in a solid state, in which the polypeptide is stabilised against degradation under physiological conditions or conditions that go beyond the limits for a long period of time. Stabilised polypeptide particles, which contain a polypeptide chosen from a super family polypeptide, which activates adenylate cyclase of the hypophysis/glucagons, and a stabilising agent chosen from disaccharides and monosaccharides, which are stable at a chosen acidic pH value, in this case the particles are made from a water solution, which has a chosen acidic pH value and are stable at temperatures till 60°C for a period of at least two months. The solid polypeptide particles under this particular invention provide stabilisation of the polypeptide, allowing them to achieve 96% restoration of the stabilised polypeptide after storage. ^ EFFECT: development of an effective way of getting stabilised polypeptide form in a solid state. ^ 11 cl, 7 ex, 9 dwg, 8 tbl |
