| 摘要 |
2072126 9110644 PCTABS00006 Compounds of formula (I), wherein A completes a 4 to 7 membered carbocyclic ring which may be saturated or mono-unsaturated and which may optionally be fused to a further saturated or unsaturated 5 or 6 membered carbocyclic ring; R is H, C1-C6 alkyl, benzyl or an alternative biolabile ester-forming group; R1 is H or C1-C4 alkyl; R2 is H, OH, C1-C4 alkyl, C1-C4 alkoxy, halo or CF3; R3 is CH2OH or CO2R4 where R4 is as defined for R; and R5 is defined to include a range of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and substituted alkyl groups including in particular methoxyethyl, S-lysylamino-methyl, N2-acetyl-S-lysylaminomethyl and N2-methanesulphonyl-S-lysyl-aminomethyl, are atriopeptidase inhibitors of utility in the treatment of hypertension, heart failure, renal insufficiency and other disorders
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