| 摘要 |
<p>NEW MATERIAL:The compound of formula I (R<1> is H or methyl; R<2> and R<3> are H or lower alkyl; R<4> is H or negative charge; Q is heterocyclic group such as pyridyl, pyrazinyl, pyrimidinyl and imidazolyl; m is 0-2; n is 0 or 1; the N atom of the heterocyclic group is N-methylated when R<4> is negative charge). EXAMPLE:Sodium (5R,6S)-2-[carbamoyl(2-pyridyl)methyl]thio-6-[(1R)-1- hydroxyethyl]-1-carbapen-2-em-3-carboxylate of formula II. USE:A remedy for microbism. PREPARATION:A compound of formula III is made to react with a compound of formula IV and, as necessary, the reaction product is subjected to N- methylation reaction and the protecting group is removed.</p> |
