发明名称 |
Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
摘要 |
Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
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申请公布号 |
US5851828(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19940284391 |
申请日期 |
1994.08.02 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
SEED, BRIAN;BANAPOUR, BABAK;ROMEO, CHARLES;KOLANUS, WALDEMAR |
分类号 |
C12N15/09;A61K35/12;A61K35/14;A61K35/26;A61K38/00;A61K39/00;A61K39/21;A61K48/00;A61P31/12;C07H21/04;C07K14/705;C07K14/725;C07K14/73;C07K14/735;C07K19/00;C12N5/10;C12N9/12;(IPC1-7):C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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