发明名称 |
Method for producing model animals for itching induced by disruption of cutaneous barrier function |
摘要 |
The present invention provides itching model animals usable for evaluating the therapeutic effect of medicines, medicinal compositions, external preparations for the skin, etc. on itching induced by hypofunction of cutaneous barrier and also for evaluating the effect in improving the barrier function of the skin weakened and converted to be itchy by an external preparation for the skin or a cosmetic. The present invention also provides a method for producing such animals. Itching symptoms are realized by degreasing the glabrous skin of each of small test animals with an organic solvent and then treating the skin with water to induce a lesion of the skin by the disruptions of the barrier function without inflammation.
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申请公布号 |
US2001042520(A1) |
申请公布日期 |
2001.11.22 |
申请号 |
US20010829905 |
申请日期 |
2001.04.11 |
申请人 |
KURAISHI YASUSHI;MIYAMOTO TAKAYUKI |
发明人 |
KURAISHI YASUSHI;MIYAMOTO TAKAYUKI |
分类号 |
A01K67/027;A01K13/00;A01K29/00;(IPC1-7):A01K29/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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