| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel analogues of 2',5'-oligoadenylate represented by the general formula (1): or their pharmacologically acceptable salts possessing antiviral and antitumor activity, to a pharmaceutical composition based on thereof, and their using as a medicinal agent in preparing a medicinal agent. In the formula (1) E1 represents group of the formula (K2): ; E2 represents group of the formula (K1): ; E3 represents group of the formula (K2) or (K3): , and E4 represents group of the formula (K1), (K2), (K3) or (K4): . Values of substitutes R1 - R8, m, n, A, B and D are given in the invention claim. ^ EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. ^ 10 cl, 4 tbl, 1 graph, 90 ex |
