| 主权项 |
1. A compound, or a pharmaceutically acceptable salt thereof, said compound having the structural Formula (I): or a tautomer thereof having the structural Formula (I′): or pharmaceutically acceptable salt thereof, wherein: RN is selected from the group consisting of alkyl, haloalkyl, heteroalkyl, and —(C1-6alkyl)-cycloalkyl, wherein said heteroalkyl is optionally substituted with halogen; R1A is independently selected from the group consisting of: H, halogen, alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein each said alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R1A is optionally unsubstituted or substituted with one or more halogen; R1B is selected from the group consisting of H, halogen, alkyl, and heteroalkyl, wherein said alkyl and heteroalkyl of R1B are each optionally unsubstituted or substituted with one or more halogen; or, alternatively, R1B is a moiety having the formula: wherein k is 0 or 1; -LC- (when present) is a divalent moiety selected from the group consisting of lower alkyl and lower heteroalkyl, wherein each said lower alkyl and lower heteroalkyl is optionally substituted with one or more halogen; ring C (when present) is selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; n is 0 or more; and each RC (when present) is independently selected from the group consisting of: halogen, oxo, —OH, —CN, —SF5, —OSF5, —Si(R5C)3, —N(R6C)2, —NR7CC(O)R6C, —NR7CS(O)2R6C, —NR7CS(O)2N(R6C)2, —NR7CC(O)N(R6C)2, —NR7CC(O)OR6C, —C(O)R6C, —C(O)2R6C, —C(O)N(R6C)2, —S(O)R6C, —S(O)2R6C, —S(O)2N(R6C)2, —OR6C, —SR6C, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein said alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, of RC are each optionally independently unsubstituted or substituted with one or more groups independently selected from R8; R2 is selected from the group consisting of H, halogen, alkyl, heteroalkyl, cycloalkyl, and -alkyl-cycloalkyl, wherein each said alkyl, heteroalkyl, cycloalkyl, and -alkyl-cycloalkyl is optionally substituted with one or more halogen; R3 is selected from the group consisting of H, halogen, alkyl, heteroalkyl, cycloalkyl, and -alkyl-cycloalkyl, wherein each said alkyl, heteroalkyl, cycloalkyl, and -alkyl-cycloalkyl is optionally substituted with one or more halogen; R4 is selected from the group consisting of H, alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein each said alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl is optionally substituted with one or more halogen; ring A is selected from the group consisting of aryl, monocyclic heteroaryl, and a multicyclic group; m is 0 or more; each RA (when present) is independently selected from the group consisting of: halogen, oxo, —OH, —CN, —SF5, —OSF5, —Si(R5A)3, —N(R6A)2, —OR6A, —SR6A, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein said alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of RA are each optionally independently unsubstituted or substituted with one or more groups independently selected from R8; -L1- is a divalent moiety selected from the group consisting of —NHC(O)— and —C(O)NH—; RL is selected from the group consisting of alkyl and heteroalkyl, wherein said alkyl and heteroalkyl of RL are each optionally unsubstituted or substituted with one or more halogen; or, alternatively, RL is a moiety having the formula wherein q is 0 or 1; -LB- (when present) is a divalent moiety selected from the group consisting of lower alkyl and lower heteroalkyl, wherein each said lower alkyl and lower heteroalkyl is optionally substituted with one or more halogen; ring B is selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; p is 0 or more; and each RB (when present) is independently selected from the group consisting of: halogen, oxo, —OH, —CN, —SF5, —OSF5, —Si(R5B)3, —N(R6B)2, —NR7BC(O)R6B, —NR7BS(O)2R6B, —NR7BS(O)2N(R6B)2, —NR7BC(O)N(R6B)2, —NR7BC(O)OR6B, —C(O)R6B, —C(O)OR6B, —C(O)N(R6B)2, —S(O)R6B, —S(O)2R6B, —S(O)2N(R6B)2, —OR6B, —SR6B, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein said alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, of RB are each optionally independently unsubstituted or substituted with one or more groups independently selected from R9; each R5A, R5B, and R5C (when present) is independently selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein each said alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R5A, R5B, and R5C is unsubstituted or substituted with one or more halogen; each R6A and R6C (when present) is independently selected from the group consisting of H, alkyl, -alkyl-OH, alkenyl, alkynyl, heteroalkyl, -heteroalkyl-OH, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl wherein each said alkyl, -alkyl-OH, alkenyl, alkynyl, heteroalkyl, -heteroalkyl-OH, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R6A and R6C is unsubstituted or substituted with one or more groups independently selected from halogen, alkyl, cycloalkyl, heteroalkyl, haloalkyl, alkoxy, heteroalkoxy, and haloalkoxy; each R6B (when present) is independently selected from the group consisting of H, alkyl, -alkyl-OH, alkenyl, alkynyl, heteroalkyl, -heteroalkyl-OH, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein each said alkyl, -alkyl-OH, alkenyl, alkynyl, heteroalkyl, -heteroalkyl-OH, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R6B is unsubstituted or substituted with one or more groups independently selected from halogen, alkyl, cycloalkyl, heteroalkyl, haloalkyl, alkoxy, heteroalkoxy, and haloalkoxy; each R7B, and R7C (when present) is independently selected from the group consisting of H, alkyl, heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein each said alkyl, heteroalkyl, -heteroalkyl-OH, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R7B, and R7C is unsubstituted or substituted with one or more halogen; each R8 (when present) is independently selected from the group consisting of halogen, lower alkyl, lower heteroalkyl, lower alkoxy, lower cycloalkyl, and lower heterocycloalkyl, wherein each said lower alkyl, lower heteroalkyl, lower alkoxy, lower cycloalkyl, and lower heterocycloalkyl of R8 is optionally substituted with halogen; and each R9 (when present) is independently selected from the group consisting of halogen, —OH, —CN, —SF5, —OSF5, alkyl, -alkyl-OH, heteroalkyl, -heteroalkyl-OH, alkoxy, —O-heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, —O-alkyl-cycloalkyl, -heterocycloalkyl, -alkyl-heterocycloalkyl, —O-heterocycloalkyl and —O-alkyl-heterocycloalkyl, wherein each said alkyl, -alkyl-OH, heteroalkyl, -heteroalkyl-OH, alkoxy, —O-heteroalkyl, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, —O-alkyl-cycloalkyl, -heterocycloalkyl, -alkyl-heterocycloalkyl, —O-heterocycloalkyl and —O-alkyl-heterocycloalkyl are optionally substituted with one or more halogen. |
