摘要 |
Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[2-(1-benzylpiperizin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo[3,4-b]quinolin-1-one hemifumarate, referred to herein as Compound A ("Cm.A"). |
申请人 |
ARENA PHARMACEUTICALS, INC.;SSP CO., LTD.;CHALMERS, DEREK, T.;SATO, SUSUMOTO;KODA, TADAYUKI |
发明人 |
CHALMERS, DEREK, T.;SATO, SUSUMOTO;KODA, TADAYUKI |