| 摘要 |
2095842 9208801 PCTABS00013 Disclosed is a bridging antibody construct including a heavy chain variable region which, when combined with a light chain variable region, binds to a surface antigen on an effector cell; a heavy chain constant region comprising a CH3 domain; and a non-immunoglobulin binding agent which binds a surface protein on a target cell. The binding agent is peptide-bonded to the carboxy terminus of said CH3 domain. Also disclosed are a nucleic acid sequence encoding the construct, a cell line transfected with that nucleic acid, a method of producing the construct, and methods of selectively killing a target cell using the construct.
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