发明名称 |
Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
摘要 |
The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.
|
申请公布号 |
US2002002282(A1) |
申请公布日期 |
2002.01.03 |
申请号 |
US20010771825 |
申请日期 |
2001.01.29 |
申请人 |
CAZER FREDERICK DANA;PARRY GREGORY EUGENE;BILLINGS DENNIS MICHAEL;REDMAN-FUREY NANCY LEE |
发明人 |
CAZER FREDERICK DANA;PARRY GREGORY EUGENE;BILLINGS DENNIS MICHAEL;REDMAN-FUREY NANCY LEE |
分类号 |
A61K31/663;A61K31/675;A61P3/14;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P25/00;A61P29/00;C07F9/58;(IPC1-7):C07F9/58 |
主分类号 |
A61K31/663 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|