Biomarkers for determining breast cancer bone metastasis

摘要

The invention provides biomarkers and biomarker profiles that discriminate between a subject with breast cancer that has metastasized to the bone and a subject with breast cancer that has not metastasized to the bone. In particular, the biomarker and biomarker profile include polypeptides present or present at higher levels in the circulatory system of subjects having breast cancer bone metastasis compared to subjects having breast cancer without bone metastasis.

主权项

1. A method for detecting breast cancer bone metastasis in a subject with breast cancer, the method comprising:
a. obtaining a biological sample from the subject; b. determining whether the plasma sample has the biomarker profile comprising SELDI polypeptide peaks M4260.92 Da, M4133.27 Da, and M4740.39 Da using SELDI-TOF mass spectrometry, and c. identifying the subject as having bone metastasis levels of the when SELDI polypeptide peaks M4260.92 Da, M4133.27 Da are increased and SELDI polypeptide peak M4740.39 Da is decreased in the sample as compared to the levels of M4260.92 Da, M4133.27 Da, and M4740.39 Da in a beast cancer subject without bone metastasis.