COMPOSITION FOR PREVENTING, IMPROVING OR TREATING BRAIN DISEASES COMPRISING EXTRACT OF VITIS LABRUSCANA OR QUERCETIN-3-O-GLUCURONIDE ISOLATED FROM THE EXTRACT

摘要

The present invention relates to a composition for preventing, alleviating or treating brain diseases, comprising a Vitis labruscana leaf extract or quercetin-3-o-glucuronide isolated therefrom as an active ingredient. More specifically, the composition for preventing, alleviating or treating brain diseases contains, as an active ingredient, a Vitis labruscana leaf extract obtained by extracting Vitis labruscana leaves in 30-50% ethanol and 1-3% acetic acid, or quercetin-3-O-glucuronide obtained by fractioning the Vitis labruscana leaf extract in n-hexane, CH_2CL_2, EtOAc, and BuOH in this order. The composition according to the present invention contains 10-80 M of quercetin-3-O-glucuronide in mouse BV2 microglial cells (510^5 cells/well), and has the effects of reducing the expression of iNOS and COX-2 while having no cytotoxicity, reducing the production of NO and PGE_2, and reducing the expression of inflammatory cytokine IL-1 and TNF-. Also, the composition according to the present invention has the effects of improving short-term working memory and spatial working memory.