| 摘要 |
Isocyanides of the formula WHEREIN Z represents oxygen or sulfur; R represents hydrogen, halogen, lower alkyl, lower alkoxy, phenyl-lower alkylene, phenyl-lower alkyloxy, trifluoromethyl, cyano, or dimethylaminosulfonyl; R1 and R2 represent hydrogen, halogen, lower alkyl, lower alkoxy, phenyl-lower alkylene, phenyl-lower alkyloxy, trifluoromethyl, cyano, dimethylaminosulfonyl, or isocyanido; and n is 1 or 2, provided that at least one of R1 and R2 is hydrogen, and that when R is other than hydrogen, R and the isocyanido group are positioned, respectively, either ortho and para or para and ortho with respect to Z. These compounds possess utility as antibacterial and parasiticidal agents. They have also demonstrated activity as CNS depressants.
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