METHODS FOR DETECTION OF CARCINOMA METASTASES BY NUCLEIC ACID AMPLIFICATION

摘要

RAN 4095/66 Methods are provided for detecting carcinoma metastases in selected body tissue or fluid. These methods offer enhanced sensitivity compared to prior standard diagnostic methods. In one embodiment of the invention, target carcinoma associated nucleic acid sequences are identified for detecting minimal residual disease in lung carcinomas. The methods utilize nucleic acid amplification techniques, preferably, the polymerase chain reaction.