| 摘要 |
Isolated nucleic acid encoding FGF mutein polypeptides, the mutein polypeptides and compositions containing the mutein polypeptides are provided. FGF mutein polypeptides that exhibit increased binding affinity for FGF receptors and reduced mitogenic activity are provided, and may be used in methods for treating FGF-mediated disorders, such as ophthalmic disorders, tumorigenic disorders and restenosis. Also provided are FGF mutein polypeptides that exhibit reduced receptor binding activity, but retain the ability to bind to heparin. Methods for treating heparin-related disorders by administering a therapeutically effective amount of an FGF mutein are also provided. |
