MUTANT CORYNEBACTERIUM AMMONIAGENES STRAIN WITH ENHANCED 5'-INOSINIC ACID PRODUCTION AND METHOD FOR PREPARING OF 5'-INOSINIC ACID USING THE SAME

摘要

The present invention relates to a method for producing Corynebacterium ammoniagenes mutant strain having the productivity of 5′-inosinic acid (IMP) having reinforced activities of transketolase, transaldolase, glucose-6-phosphate 1-dehydrogenase, hetero multimeric protein, and 6-phosphogluconolactonase, and to a method for producing IMP by using the same. The strain according to the present invention not only reinforces a promoter of a major gene so as to enhance metabolism of a pentose sugar circuit but also preferably reduces an activity of a glucose isomerase of a central metabolism route which is a competition circuit, so IMP productivity is increased compared to Corynebacterium ammoniagenes which is a base strain.