| 摘要 |
Novel compounds of the Formula I, wherein R represents an alkenyl group of more than 4 carbon atoms or an R1-(CH2)ngroup where R1 represents a thienyl, tetrahydropyranyl, pyridyl, pyrrolidino or piperidino group and n is 1 or 2, and salts thereof, are prepared by hydrolysing a nitrile of the Formula II with an alkali in the presence of an alcohol and, if desired, acidifying the resulting salt to obtain the free acid. The free acids may be converted into other salts. (I) <FORM:1046429/C2/1> (II) <FORM:1046429/C2/2> Nitriles of the Formula II may be prepared by treating 2-(1-naphthyl) acetonitrile with an alkaline reagent, capable of reacting with the acetonitrile to form an alkali metal derivative thereof which is thereafter reacted with a halogen compound represented by the formula RX wherein X represents a halogen atom, or by condensing a compound containing the radical R with acetonitrile to form an intermediate compound which on reaction, with a 1-halonaphthalene gives the desired nitrile. Therapeutic compositions with anti-inflammatory, analgesic, hypocholesterolemic, antispasmodic and anti-histaminic properties; for oral, parenteral and topical application; comprise compounds of the Formula I or nontoxic, pharmaceutically acceptable salts thereof together with one or more pharmaceutical diluents and/or excipients. |
