BAFF MUTANTS WITH AT LEAST ONE AMINO ACID SUBSTITUTION AND METHODS OF THEIR PRODUCTION

摘要

The invention relates to BAFF protein mutants carrying at least one amino ac id substitution at one position having dominant negative antagonist activity, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the BAFF protein mutants in the treatment of BAFF or APRIL-related disorders.