| 摘要 |
<p>N-vinyl lactams marked with hydrogen isotopes in (Alpha)-position of the lactam ring of a general formula. (FORMULA) where n = 2-4, R1 = H, D, T and R2 = D, T. The method of obtaining the above combinations consists in subjecting the initial N-vinyl lactam to the treatment with denterium oxide or with water containing tritium, at a pH = 10.5 to 14 with the use, as a catalyst, of an alkaline metal hydroxide or a base NR40H, where R means CH3 or C2H5, in the presence of an organic solvent or without it, with subsequent separation of the desired product. N-vinyl lactams may be used for the synthesis of homo- or copolymers marked with hydrogen isotopes in a strictly fixed position, which, in their turn, may be used in the medical field as diagnostic means and for research purposes. </p> |
