发明名称 |
SYNTHESIS OF BICYCLIC AROMATIC SULFONIC ACIDS, SULFONYL CHLORIDES AND SULFONAMIDES |
摘要 |
This invention provides a novel process for the synthesis of bicyclic aromatic sulfonic acids employing reacting a bicyclic aromatic compound with sulfur trioxideN,N-dimethylformamide complex in the presence of a water miscible, non-reactive solvent. The resulting sulfonic acid may be converted into the corresponding sulfonyl halide by the reaction with a thionyl halide. This invention further provides a novel process for the synthesis of bicyclic aromatic sulfonamides employing the reaction conditions described supra followed by an ammonolysis or amination. The resulting bicyclic aromatic sulfonamides can then be reacted with an appropriately substituted isocyanate to synthesize diaryl sulfonylureas.
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申请公布号 |
CA2103930(A1) |
申请公布日期 |
1994.02.20 |
申请号 |
CA19932103930 |
申请日期 |
1993.08.12 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
MILLER, WILLIAM D.;TAO, EDDIE V. |
分类号 |
C07D;C07D263/56;C07D265/36;C07D307/79;C07D311/04;C07D317/50;C07D317/62;C07D319/18;C07D319/20;(IPC1-7):C07D307/79;C07D209/08 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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