| 摘要 |
2-Mercaptoimidazoles I(R1,R2 = heteroaryl, aryl; R3 = H, lower alkyl; R4 = alip. hydrocarbon; n = 1, 2), useful as antiinflammatory, anodyne and/or cerebral thrombosis-treating agent, were prepd. by reacting compds. II (X = sulfinic acid or sulfonic acid group) with compds. III(Y = reactive esterified hydroxy group). Thus, 0.23 g Na was dissolved in 100 ml EtOH and 3 g 4(5)-(p-fluorophenyl)-5(4)-(2-thienyl-imidazole-2-sulfonic acid and EtOH 50 ml contg. ethyliodide 1.62 g added and refluxed for 4 hr to give 2-ethanesulfonyl-4(5)-(p-fluorophenyl)-5(4)-(2-thienyl)-imidazole(m.p. 181≰C).
|
