发明名称 |
Production and use of bacterial histamine |
摘要 |
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. In particular the present invention relates to a method of selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, wherein said method comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions. |
申请公布号 |
AU2012285657(B2) |
申请公布日期 |
2017.02.16 |
申请号 |
AU20120285657 |
申请日期 |
2012.07.20 |
申请人 |
BioGaia AB |
发明人 |
Versalovic, James;Thomas, Carissa Michelle;Connolly, Eamonn |
分类号 |
A23L33/135;A61K35/74;G01N33/569 |
主分类号 |
A23L33/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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