PROTEIN KINASE INHIBITOR CONTAINING PYRROLOPYRIDAZINE DERIVATIVE

摘要

The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt thereof. The compound according to the present invention and a pharmaceutically acceptable salt thereof can inhibit the activity of protein kinase(s), and thus are useful for preventing or treating diseases related thereto.

主权项

1. A compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof: wherein, in Formula 1, R1 is H or halogen; R2 is aryl or heteroaryl selected from the group consisting of indolyl, phenyl, pyrazinyl, pyrazolyl, pyridinyl, pyrimidinyl, thiazolyl, and thienyl, wherein the aryl or the heteroaryl is unsubstituted or substituted with one or two substituents, which are respectively and independently selected from the group consisting of  C1-4 alkyl, C1-4 alkoxy, halogen, nitro, cyano, amino, NH(C1-4 alkyl), NH-acetyl, CO—H, CO—(C1-4 alkyl), CO-morpholino, CO—NH2, CO—NH(C1-4 alkyl), CO—N(C1-4 alkyl)2, morpholino, piperazinyl, piperidinyl, SO2—(C1-4 alkyl), SO2—NH2, SO2—NH(C1-4 alkyl), and SO2—N(C1-4 alkyl)2; wherein Ri is selected from the group consisting of hydroxy, O—CH2CH2—O—CH3, OCO—NH2, morpholino, amino, NH(C1-4 alkyl), and N(C1-4 alkyl)2; Rii is hydroxy or C1-4 alkoxy; and Riii is hydroxy; and R3 is  wherein Ra is H or C1-4 alkoxy; Rb is H or halogen; and Rc is H or C1-4 alkyl.