| 摘要 |
1,238,777. Aminoalkylphenols. HASSLE A.B. 31 March, 1969 [1 April, 1968], No. 16831/69. Heading C2C. Compounds of the general Formula (III) (R<SP>1</SP> = C 1-3 alkyl; R<SP>2</SP> = F, Cl, Br, C 1-3 alkyl) and their salts are prepared by (a) subjecting a compound of the Formula (IV) (Z = alkyl, acyl) to de-etherification or deesterification, respectively, in the presence of a strong acid; (b) catalytically hydrogenating a compound of the Formula (IV) (R<SP>2</SP> = C 1-3 alkyl; Z = aralkyl); (c) reducing a compound of the Formula (V) in the presence of formic acid under the conditions of the Leuckart reaction; (d) reducing a compound of the Formula (VI) (R<SP>2</SP> = C 1-3 alkyl); or (e) reducing a compound of the Formula (VII) optionally followed in each case by salt formation and/or resolution. The preparation of starting materials for processes (a) and (e) by standard methods is described. The above compounds possess antihypertensive and antidepressant properties and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. |
