| 摘要 |
3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H -3-benzazepine derivatives are prepared by N-allylation of 7,8-dimethoxy-6-halo-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benza zepine using an allyl halide in acetonitrile in the presence of base followed by O-demethylation. These compounds have a unique cardiovascular effect in that they are potent renal vasodilators and also induce bradycardia.
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