| 摘要 |
PURPOSE: Provided is a novel olefination process which is useful for making certain itaconate and succinate derivatives. CONSTITUTION: An efficient and selective process is capable of scale-up, to make itaconate derivatives of formula(4), and/or succinate derivatives of formula(5) and/or(6) by asymmetric hydrogenation of the itaconate derivatives. The process comprises formation of a compound of formula(4) by reaction of an aldehyde of formula RCHO with a phosphorus compound of formula(9): or a metal carboxylate optionally followed by, if a compound of formula(5) or(6) is desired, asymmetric reduction of a compound of formula(4) to provide a compound of formula(5) or(6).
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