| 发明名称 |
Pharmaceutical composition with improved bioavailability |
| 摘要 |
The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds. |
| 申请公布号 |
US9427427(B2) |
申请公布日期 |
2016.08.30 |
| 申请号 |
US201414159679 |
申请日期 |
2014.01.21 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
Lomuscio Steve;Ma Hua;Matchett Michael Allen;Sandhu Harpreet K.;Shah Navnit Hargovindas;Zhang Yu-E |
| 分类号 |
A61K31/40;A61K9/10;A61K9/14;A61K9/16;A61K47/38;A61K9/20 |
主分类号 |
A61K31/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A physically stable solid dispersion comprising compound (A): and a stabilizing polymer, wherein said stabilizing polymer is Poly(methacylic acid)-co-methyl methacrylate or Poly(vinylpyrrolidone-co-vinyl acetate)(6+4). |
| 地址 |
Nutley NJ US |
