Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido¬1,2-a pyrimidin-4-one derivatives

摘要

The invention relates to a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: <CHEM> wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the rings being optionally substituted; R2 represents a phenyl group or a naphthalene ring; the phenyl group and the naphthalene ring being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group; R4 represents a C1-2 perhalogenated alkyl group or a C1-3 halogenated alkyl group; R5 represents a hydrogen atom; a C1-6 alkyl group or a halogen atom; n represents 0 to 3; and p+q=0-3. <??>The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta , such as Alzheimer disease.