| 摘要 |
Compounds of the formula I are described: wherein one of the radicals X1, X2 or X3 represent C-O-R2 the respective others X1, X2, X3 and X4 are then equal or different, N or CR1; R1 and R3 equal or different, are H, halogen, (C1-C6) alkyl, O-R6, S-R6, (C6-C12) aryl, (C6-C12)aryl- (C2-C3) alkyl, C(O)-OR6, C(O)-H, (C2-C5)alkenyl, NO2, SO3R7, CN or C(O)-NHRS, can be alkyl, aryl and eventually substituted alkenyl; R2 is a compound of the formula (II) R4 and R5 equal or different are H, halogen, OR6, SR6, CN or (C1-C5)alkyl; R6, R7 and R8 equal or different are H, (C1-C5) alkyl, alkenyl (C3-C5), (C6-C12) aryl- (C1-C3) alkyl, (C3-C10) cycloalkyl, (C3-C10) cycloalkyl- (C1-C3) alkyl, C(O)-(O)0-1-(C1-C5) alkyl or C(O)- (NH) 0-1-(C1-C5)alkyl or C(O)-(O)0-1- (C-1-C5)alkyl or C(O)- (NH) 0-1-(C1-C5) alkyl or C(O)-(O)0-1-(C1-C3)alkyl- (C6-C10) aryl; R10 is -C(O)-D-E, -C(S)-D-E, -SO2-D-E or hydrogen; D is (C2-C5) alkendylyl, (C1-C8) alkandylyl, -(CH2)n-Yo-(CH2)m-, (C3-C10) cycloalkandylyl, (C3-C10) cycloalkyl-(C1-C3) alkandylyl, which eventually can be substituted; E is H, (C6-C10) aryl or (C1-C9) heteroaryl which eventually an be substituted; Y is O, S o NR8; as well as its physiologically compatible salts, a process for its preparation and its use as therapeutic and curative agents.
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